Polygenic Study of Endurance-Associated Genetic Markers NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val), AMPD1 (Gln45Ter) and ACE (I/D) in Polish Male Half Marathoners

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F18%3A10383505" target="_blank" >RIV/00216208:11510/18:10383505 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1515/hukin-2017-0204" target="_blank" >https://doi.org/10.1515/hukin-2017-0204</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/hukin-2017-0204" target="_blank" >10.1515/hukin-2017-0204</a>

Result language

angličtina

Original language name

Polygenic Study of Endurance-Associated Genetic Markers NOS3 (Glu298Asp), BDKRB2 (-9/+9), UCP2 (Ala55Val), AMPD1 (Gln45Ter) and ACE (I/D) in Polish Male Half Marathoners

Original language description

The purpose of this study was to investigate individually and in combination the association between the ACE (I/D), NOS3 (Glu298Asp), BDKRB2 (-9/+ 9), UCP2 (Ala55Val) and AMPD1 (Gln45Ter) variants with endurance performance in a large, performance-homogenous cohort of elite Polish half marathoners. The study group consisted of 180 elite half marathoners: 76 with time &lt; 100 minutes and 104 with time &gt; 100 minutes. DNA of the subjects was extracted from buccal cells donated by the runners and genotyping was carried out using an allelic discrimination assay with a C1000 Touch Thermal Cycler (Bio-Rad, Germany) instrument with TaqMan (R) probes (NOS3, UCP2, and AMPD1) and a T100 (TM) Thermal Cycler (Bio-Rad, Germany) instrument (ACE and BDKRB2). We found that the UCP2 Ala55Val polymorphism was associated with running performance, with the subjects carrying the Val allele being overrepresented in the group of most successful runners (&lt; 100 min) compared to the &gt; 100 min group (84.2 vs. 55.8%; OR = 4.23, p &lt; 0.0001). Next, to assess the combined impact of 4 gene polymorphisms, all athletes were classified according to the number of &apos;endurance&apos; alleles (ACE I, NOS3 Glu, BDKRB2 -9, UCP2 Val) they possessed. The proportion of subjects with a high (4-7) number of &apos;endurance&apos; alleles was greater in the better half marathoners group compared with the &gt; 100 min group (73.7 vs. 51.9%; OR = 2.6, p = 0.0034). These data suggest that the likelihood of becoming an elite half marathoner partly depends on the carriage of a high number of endurance-related alleles.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30306 - Sport and fitness sciences

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Human Kinetics

ISSN

1640-5544

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

12

Pages from-to

87-98

UT code for WoS article

000447662500009

EID of the result in the Scopus database

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