Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F20%3A10400598" target="_blank" >RIV/00216208:11510/20:10400598 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oU3gI7ixlS" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oU3gI7ixlS</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.comppsych.2019.152143" target="_blank" >10.1016/j.comppsych.2019.152143</a>
Alternative languages
Result language
angličtina
Original language name
Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort
Original language description
Background: Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression.Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of devel-oping depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from thesame individuals are scarce.Methods: We have examined whether longitudinal patterns of inflammation, based on three CRP measure-ments from childhood to early-adulthood, are associated with the risk of depression in early-adulthoodin the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.Results: Using Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identifiedfour population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low(N = 463, 29.5%); persistently high (N = 371, 24%); decreasing (N = 360, 23%); increasing (N = 367, 23.5%).The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood.Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared withthose with persistently low CRP; adjusted odds ratio (OR) = 3.78 (95% Confidence Interval (CI), 1.46-9.81;p = 0.006). The odds of moderate/severe depression were also increased for the persistently high CRPgroup, but this was not statistically significant; OR = 2.54 (95% CI, 0.90-7.16).Limitations: Repeat CRP measures were available for a subset, who may not be representative of all cohortparticipants.Conclusions: The results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30306 - Sport and fitness sciences
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Comprehensive Psychiatry
ISSN
0010-440X
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
neuvedeno
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1-7
UT code for WoS article
000525757200006
EID of the result in the Scopus database
2-s2.0-85074455744