Evidence of hypothalamic-pituitary-adrenal and -gonadal dysfunction in cocaine-addicted men

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F24%3A10472270" target="_blank" >RIV/00216208:11510/24:10472270 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Qdd1ZMirV0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Qdd1ZMirV0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17863/CAM.104419" target="_blank" >10.17863/CAM.104419</a>

Result language

angličtina

Original language name

Evidence of hypothalamic-pituitary-adrenal and -gonadal dysfunction in cocaine-addicted men

Original language description

Regular cocaine use has been associated with hormonal dysfunction including hypogonadism, which can lead to fatigue, reduced stamina, sexual dysfunction and impaired quality of life. However, cocaine&apos;s endocrine effects are largely under-reported in the scientific addiction literature and, in many cases, are not addressed within treatment services. The low profile of these adverse effects might be attributable to a lack of awareness and linkage with cocaine use, such that they are recognized only when an acute/emergency problem arises. Methods: We assessed endocrine diurnal function [adrenocorticotrophic hormone (ACTH), cortisol and testosterone in 26 healthy and 27 cocaine-dependent men and examined changes in hormone levels in response to a single 40 mg dose of the noradrenaline re-uptake inhibitor atomoxetine in a double-blind, placebo-controlled experimental medicine study. Results: When compared with healthy controls, diurnal and atomoxetine-induced changes in ACTH and cortisol showed greater variability in cocaine-dependent men. Interestingly, despite an exaggerated rise in ACTH following atomoxetine, an attenuated cortisol response was observed, and one third of cocaine-dependent men had subnormal testosterone levels. Conclusion: Our findings point to a potential disconnection between the pituitary and adrenal responses in cocaine-dependent men, a higher rate of hypogonadism, and a pressing need for more research into the endocrine effects of cocaine and their clinical implications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30306 - Sport and fitness sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Addiction Research

ISSN

1022-6877

e-ISSN

1421-9891

Volume of the periodical

30

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

114-120

UT code for WoS article

001144195600001

EID of the result in the Scopus database

2-s2.0-85182890224