High-dose medium-term HMB supplementation did not trigger body composition changes in trained and untrained males under usual conditions or high-intensity functional exercise

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11510%2F25%3A10504870" target="_blank" >RIV/00216208:11510/25:10504870 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HZTZa4Vehe" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HZTZa4Vehe</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnut.2025.1681465" target="_blank" >10.3389/fnut.2025.1681465</a>

Result language

angličtina

Original language name

High-dose medium-term HMB supplementation did not trigger body composition changes in trained and untrained males under usual conditions or high-intensity functional exercise

Original language description

Introduction: beta-hydroxy-beta-methylbutyrate (HMB) supplementation may support fat-free mass (FFM) increase and fat mass (FM) decrease. Its utility has been studied mainly for 3 g(HMB)&lt;middle dot&gt;day(-1) and long-term supplementation (e.g., 12 weeks). Therefore, new and personalized effective HMB supplementation protocols should be verified. Methods: Ninety trained (TR, n = 53; 29.1 +/- 7.7 years; FFM: 84.1 +/- 5.1%) and untrained (UTR, n = 37; 32.3 +/- 7.6 years; FFM: 75.7 +/- 7.7%) males completed the randomized parallel-group placebo (PLA)-controlled study aiming at evaluating the influence of new individualized high-dose mid-term liquid HMB free acid supplementation protocol (90 mg(HMB)&lt;middle dot&gt;kg(FFM)(-1)&lt;middle dot&gt;day(-1)) alone (3 weeks; first period) and combined with high-intensity functional training (HIFT; 3 weeks; second period) on body mass (BM), FFM and FM, and total body water (TBW). The Fight Gone Bad (FGB) workout was an additional HIFT stimuli (2 units&lt;middle dot&gt;week(-1)). Testing was performed at baseline (BAS) and after the first (SUP) and the second (SUP+FGB) study periods. Results: HMB doses were 4.8-7.8 g(HMB)&lt;middle dot&gt;day(-1). The intervention had no significant effect on BM, FFM, FM, or TBW. BM, FFM (kg), TBW, and TBW/FFM were higher at SUP+FGB vs. BAS regardless of the implemented treatment and training status. Nevertheless, there was an impact (p &lt; 0.05) from training status (but not HMB/PLA) on FM (kg; slight increases in UTR) and TBW (slight decreases in UTR). Discussion: The individually adjusted high HMB dose did not change body mass and composition in trained or untrained individuals during a three-week exclusive supplementation or three-week supplementation in combination with additional HIFT stimuli. Therefore, any modifications in this area may likely require a longer treatment period.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30306 - Sport and fitness sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Nutrition

ISSN

2296-861X

e-ISSN

2296-861X

Volume of the periodical

12

Issue of the periodical within the volume

September

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1681465

UT code for WoS article

001589659500001

EID of the result in the Scopus database

2-s2.0-105018818899