Importance of vaccine action and availability and epidemic severity for delaying the second vaccine dose

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11640%2F22%3A00559293" target="_blank" >RIV/00216208:11640/22:00559293 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/22:00557330 RIV/67985807:_____/22:00557330 RIV/67985556:_____/22:00557330 RIV/60076658:12310/22:43904745 RIV/00216208:11320/22:10456530

Result on the web

<a href="https://doi.org/10.1038/s41598-022-11250-4" target="_blank" >https://doi.org/10.1038/s41598-022-11250-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-022-11250-4" target="_blank" >10.1038/s41598-022-11250-4</a>

Result language

angličtina

Original language name

Importance of vaccine action and availability and epidemic severity for delaying the second vaccine dose

Original language description

Following initial optimism regarding potentially rapid vaccination, delays and shortages in vaccine supplies occurred in many countries during spring 2021. Various strategies to counter this gloomy reality and speed up vaccination have been set forth, of which the most popular has been to delay the second vaccine dose for a longer period than originally recommended by the manufacturers. Controversy has surrounded this strategy, and overly simplistic models have been developed to shed light on this issue. Here we use three different epidemic models, all accounting for then actual COVID-19 epidemic in the Czech Republic, including the real vaccination rollout, to explore when delaying the second vaccine dose by another 3 weeks from 21 to 42 days is advantageous. Using COVID-19-related deaths as a quantity to compare various model scenarios, we find that the way of vaccine action at the beginning of the infection course (preventing infection and symptoms appearance), mild epidemic and sufficient vaccine supply rate call for the original inter-dose period of 21 days regardless of vaccine efficacy. On the contrary, for the vaccine action at the end of infection course (preventing severe symptoms and death), severe epidemic and low vaccine supply rate, the 42-day inter-dose period is preferable, at any plausible vaccine efficacy.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

50202 - Applied Economics, Econometrics

Project

<a href="/en/project/TL04000282" target="_blank" >TL04000282: City for People, not for Virus</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Volume of the periodical

12

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

7638

UT code for WoS article

000793383600002

EID of the result in the Scopus database

2-s2.0-85129879793