Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar]

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F00%3A00003135" target="_blank" >RIV/00216224:14110/00:00003135 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar]

Original language description

The study was undertaken to characterize changes of the activities of oxidative and conjugative hepatic enzymes, CYP2D1 and NAT2, induced by pretreatment with fluoxetine or paroxetine. Method of the isolated perfused liver from the male Wistar rat donorspretreated in vivo with SSRIs was used for the study. The results showed that the metabolic capacity of the liver for O-demethylation of dextromethorphane to dextrorphan was significantly decreased. Pretreatment with fluoxetine, but not with paroxetine,evoked also inhibition of activity of NAT2. Thus, SSRIs showed significant inhibitory effects upon the enzyme activities in the rat liver.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European psychiatry

ISSN

0924-9338

e-ISSN

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Volume of the periodical

2000

Issue of the periodical within the volume

15

Country of publishing house

FR - FRANCE

Number of pages

2

Pages from-to

384

UT code for WoS article

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EID of the result in the Scopus database

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