Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00004172" target="_blank" >RIV/00216224:14110/01:00004172 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26310/01:PU21656
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status
Original language description
BACKGROUND: The formation of advanced glycation end products (AGEs) and oxidative stress are supposed to play an important role in the development of diabetic late complications. AGEs can bind to several binding sites including Receptor of Advanced Glycation End products (RAGE). AGE-RAGE interaction results in free radical generation. The aim of the present study was to investigate the impact of previously described polymorphisms in the RAGE gene (G82S, 1704G/T, 2184A/G and 2245G/A) on the glycoxidationstatus in NIDDM. METHODS: A total of 371 unrelated Caucasian subjects were enrolled in the study. The NIDDM group comprised 202 subjects, the presence of late diabetic complications in five particular localizations was expressed as an index (Icompl). The non-diabetic group comprised 169 subjects. Glycated hemoglobin (HbA1c), glycated stratum corneum proteins (Amadori, AGE), total carotenoids, a- and b-carotene, g-tocopherol, lutein, lycopene and a-tocopherol were measured in each subjec
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/VS96097" target="_blank" >VS96097: Molecular pathophysiology of selected multigenic related to civilization diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Metabolism: Clinical and Experimental
ISSN
0026-0495
e-ISSN
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Volume of the periodical
50
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1152
UT code for WoS article
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EID of the result in the Scopus database
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