Lack of association between atopic asthma and the tumor necrosis factor alpha -308 gene polymorphism in a Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00004573" target="_blank" >RIV/00216224:14110/02:00004573 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lack of association between atopic asthma and the tumor necrosis factor alpha -308 gene polymorphism in a Czech population

Original language description

Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. Several investigators have linked the tumor necrosis factor (TNF) genes and nearby markers located on chromosome 6p to atopy and asthma. Recent study has demonstrated that the TNF-alpha*2 allele of a polymorphism in the TNF-alpha; gene promoter region (G-308 A) is associated with a higher risk for the development of atopy in Spanish patients. The objective of this study was to evaluate the possible role of two described bi-allelic polymorphisms in the TNF locus alpha;a G to A transition at position -308 in the promoter region of the TNF-alpha gene and an NcoI restriction fragment length polymorphism (RFLP) in the first intron (+252A/G) of the LT-alpha(TNF-beta) gene in atopic diseases in a Czech population. We investigated the distribution of these polymorphisms in a case-control study. The genotypes were determined in 151 patients with atopic asthma and 155 random-s

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Investigational Allergology and Clinical Immunology

ISSN

1018-9068

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

3

Country of publishing house

ES - SPAIN

Number of pages

6

Pages from-to

192

UT code for WoS article

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EID of the result in the Scopus database

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