Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00005507" target="_blank" >RIV/00216224:14110/02:00005507 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Plasminogen-Activator-Inhibitor-1 Promoter Polymorphism as a Risk Factor for Adult Periodontitis in Non-Smokers

Original language description

Periodontal diseases belong to the most common chronic disorders affecting mankind. Smoking and impaired plasminogen activation with hypercoagulation and fibrinolysis inhibition have been proposed as having a role in predisposition to these diseases We investigated relationships among adult periodontitis, smoking and a variation in the deletion/insertion (4G/5G) promoter polymorphism of the plasminogen-activator-inhibitor-1 (PAI-1) gene in 304 Caucasian subjects. An association was detected between thedeletion (4G) allele (and 4G/4G genotype) and periodontitis (p=0.0022, Pcorr.LT.0.01, p=0.014, Pcorr.LT.0.05). Even a stronger association occurred in non-smokers (p=0.00021, Pcorr.LT.0.01, p=0.0024, Pcorr.LT.0.05) where the presence of the PAI-1 gene 4Gallele appears to be one of the risk factors for periodontitis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genes Immun

ISSN

ISSN 1466-487

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

292

UT code for WoS article

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EID of the result in the Scopus database

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