Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00005552" target="_blank" >RIV/00216224:14110/02:00005552 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report

Original language description

Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured ineach subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179)and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetes & Metabolism

ISSN

03381684

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

3

Country of publishing house

FR - FRANCE

Number of pages

7

Pages from-to

231

UT code for WoS article

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EID of the result in the Scopus database

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