Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00006930" target="_blank" >RIV/00216224:14110/02:00006930 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Influence of ligands of serotonin receptors on the drug-metabolizing processes in the isolated perfused rat liver

Original language description

The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969.

Czech name

Vliv ligandů serotoninových receptorů na metabolickou aktivitu v izolovaných perfundovaných játrech potkana

Czech description

The effects of selective ligands of 5-HT3 and 5-HT1A/1B receptors, tropisetrone and RU 249, on N-acetylation and cytochrome P460-mediated metabolism in the isolated perfused rat liver were followed. The study has shown significant inhibition of acetylation, but a marked stimulation of CYP 2D1 activity after administration of both substances, with higher significance in RU 24969.

Type

D - Article in proceedings

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

46. Studentská vědecká konference

ISBN

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ISSN

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e-ISSN

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Number of pages

2

Pages from-to

24-25

Publisher name

Lékařská fakulta MU v Brně

Place of publication

Brno

Event location

Lékařská fakulta MU v Brně

Event date

Jan 1, 2002

Type of event by nationality

CST - Celostátní akce

UT code for WoS article

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