Association of Two Angiotensinogen Gene Polymorphisms (M235T and G(-6)A) with Chronic Heart Failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008558" target="_blank" >RIV/00216224:14110/03:00008558 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Association of Two Angiotensinogen Gene Polymorphisms (M235T and G(-6)A) with Chronic Heart Failure

Original language description

The aim of the study was to focus on relationship between the angiotensinogen (AGT) gene polymorphisms, M235T and promoter G(-6)A, and chronic heart failure in the Czech population. 158 patients with chronic heart failure (functional class NYHA II-IV, ejection fraction <40% cardiothoracic index >50%) were compared with control group of 200 subjects of similar age and sex distribution, without any personal history of cardiovascular diseases. The AGT gene polymorphisms were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. No significant differences in distributions of AGT genotypes between patients with chronic heart failure (CHF) and controls were found. The differences in distributions of allelesin AGT M235T (Pa=0.02) and genotypes in AGT G(-6)A (Pg=0.017) were found within women groups. Within CHF patients the distribution of AGT G(-6)A genotypes was not consistent with Hardy-Weinberg equilibrium (P=0.0001). We found significant

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

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Volume of the periodical

89

Issue of the periodical within the volume

2-3

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

267-272

UT code for WoS article

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EID of the result in the Scopus database

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