EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008889" target="_blank" >RIV/00216224:14110/03:00008889 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION

Original language description

Amisulpride, an atypical antipsychotic agent, in low doses preferentially blocks D2 and D3 dopamine autoreceptors in the limbic system. In our pre-clinical experiment we used the bilaterally-bulbectomized rat model of depression to examine whether amisulpride reduces the characteristic hyperactive locomotor responses in these rats exposed in the open-field test. Apart from the behavioural changes also amisulpride effects on the immune function of leukocyte phagocytosis in both sham-operated and bulbectomized rats were tested. Leukocyte zymosan induced phagocytosis was evaluated according to luminol aided chemiluminescence in vitro after repeated administration of amisulpride in vivo. OB rats showed a significant increase in ambulation and rearing scores in the open-field test, and suppressed leukocyte phagocytic function compared to the sham-operated rats. Repeated amisulpride administration (7mg/kg/day, intraperitoneally, for 7 days) resulted in a significant suppression of the motor

Czech name

EFFECTS OF AMISULPRIDE ON LOCOMOTOR BEHAVIOUR AND LEUKOCYTE PHAGOCYTOSIS IN RAT MODEL OF DEPRESSION

Czech description

Amisulpride, an atypical antipsychotic agent, in low doses preferentially blocks D2 and D3 dopamine autoreceptors in the limbic system. In our pre-clinical experiment we used the bilaterally-bulbectomized rat model of depression to examine whether amisulpride reduces the characteristic hyperactive locomotor responses in these rats exposed in the open-field test. Apart from the behavioural changes also amisulpride effects on the immune function of leukocyte phagocytosis in both sham-operated and bulbectomized rats were tested. Leukocyte zymosan induced phagocytosis was evaluated according to luminol aided chemiluminescence in vitro after repeated administration of amisulpride in vivo. OB rats showed a significant increase in ambulation and rearing scores in the open-field test, and suppressed leukocyte phagocytic function compared to the sham-operated rats. Repeated amisulpride administration (7mg/kg/day, intraperitoneally, for 7 days) resulted in a significant suppression of the motor

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Behavioural Pharmacology

ISSN

0955-8810

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

Suppl.1

Country of publishing house

BE - BELGIUM

Number of pages

1

Pages from-to

40-40

UT code for WoS article

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EID of the result in the Scopus database

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