Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00008970" target="_blank" >RIV/00216224:14110/03:00008970 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Inhibition of cannabinoid CB1 receptor attenuates behavioural sensitization to methamphetamine in mice

Original language description

Behavioural sensitization is typically manifested by increased behavioural responses to the drug. In our previous studies we created an original dosage regimen that produced sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice and also cross-sensitization to methamphetamine with the cannabinoid receptor agonist methanandamide. The changes in the behaviour were recorded in the open field of the Actitrack apparatus (Panlab, S. L., Spain). Methamphetamine and combined methamphetamine+AM 251 treatments were injected to the mice at the doses of 2.5 mg/kg and 5 mg/kg, respectively. On the day 8 all mice were given a "challenge dose" of methamphetamine 2.5 mg/kg to check a development of hypothesised sensitization. In the grouppre-treated with methamphetamine only, a significant behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were sign

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Neuropsychopharmacology

ISSN

0924-977X

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

Suppl. 4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

2

Pages from-to

416-417

UT code for WoS article

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EID of the result in the Scopus database

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