Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00009288" target="_blank" >RIV/00216224:14110/03:00009288 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/03:00007253

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

Original language description

The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I inour experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NF6658" target="_blank" >NF6658: Alternative approaches in brachial plexus reconstruction and experimental evaluation of various neurotrophic factors action on direct and collateral reinnervation</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of Anatomy

ISSN

0940-9602

e-ISSN

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Volume of the periodical

183

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

363

UT code for WoS article

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EID of the result in the Scopus database

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