Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F03%3A00009530" target="_blank" >RIV/00216224:14110/03:00009530 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/03:00008624

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments

Original language description

Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block.

Czech name

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Czech description

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Type

B - Specialist book

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/GP204%2F02%2FD129" target="_blank" >GP204/02/D129: Quantitative analysis of effect of tubular system on electrical activity of cardiac cells</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

80-7013-394-5

Number of pages

7

Publisher name

neuveden

Place of publication

Brno

UT code for WoS book

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