Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010246" target="_blank" >RIV/00216224:14110/04:00010246 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Sensitization and cannabinoid cross-sensitization to methamphetamine antiaggressive effects is not developed in morphine treatment design in mice

Original language description

Repeated drug administration leading to a progressively enhanced response, a phenomenon termed sensitization, may be involved in the development and maintenance of drug addiction and also relapse to drug-taking behaviour in weaned addicts. There also isdata available showing a cross-sensitization between different types of drugs of abuse. The present study observed behavioural sensitization to the psychostimulant methamphetamine (MET), the opioid morphine (MO) and cross-sensitization with cannabinoid methanandamide (CA) to both of them in mice. The model of agonistic behaviour in singly-housed male mice on paired interactions with non-aggressive group-housed partners was used to analyze behavioural changes in 15 acts of 4 categories: sociable, timid,aggressive and locomotor. Both MET and MO produce dose-dependent antiaggressive effects in singly-housed mice; MET increased while MO decreased locomotor activities. The sensitization to these effects of MET was clearly demonstrated when

Czech name

SEnsitizace a krossensitizace kanabinoidem k inhibičnímu účinku metamfetaminu na agresivitu myší se nevzniká v řpípadě aplikace morfinu

Czech description

Výsledky studie podporují údaje o funkční interakci mezi endokanabinoidním systémem a farmakologickými mechanismy účinku metamfetaminu. Paralela nebyla potvrzena u morfinu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fundamental & Clinical Pharmacology

ISSN

1744-3377

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

Suppl.1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

1

Pages from-to

58

UT code for WoS article

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EID of the result in the Scopus database

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