METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010419" target="_blank" >RIV/00216224:14110/04:00010419 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY
Original language description
Methamphetamine (pervitine) is one of the most frequently abused substances. The drug is metabolized by the hepatic cytochromes P450, mainly by CYP2D and CYP3A. The present pharmacokinetic study in the rat investigated the possible influence of methamphetamine on metabolic fates of model substrates for CYP3A1/2 and CYP2D1/2. The pharmacokinetic analysis showed a marked stimulatory effect of methamphetamine on CYP2D1/2, as it was previously demonstrated by us in the isolated perfused rat liver. Similarly, the midazolam kinetics (marker of CYP3A1/2 activity) showed a significantly increased CYP3A-mediated metabolism. The results may have clinical impact in pharmacotherapy of methamphetamine abusers.
Czech name
Methamfetaminem indukované změny v metabolismu dextromethorfanu a midazolamu u potkanů: farmakokinetická studie
Czech description
Methamfetaminem indukované změny v metabolismu dextromethorfanu a midazolamu u potkanů: farmakokinetická studie

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
19th European Workshop on Drug Metabolism. Abstract & Program Book.
ISBN
—
ISSN
—
e-ISSN
—
Number of pages
1
Pages from-to
194-194
Publisher name
Tubitak
Place of publication
Antalya (Turecko)
Event location
Antalya
Event date
Jan 1, 2004
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—

Similar results(10)