Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010521" target="_blank" >RIV/00216224:14110/04:00010521 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression

Original language description

The effects of St. Johns wort (standardized herbal extract LI 160) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat were studied. The activity of leukocyte zymosan-induced phagocytosis was examinedvia measurement of chemiluminiscence potentiated by luminol. The results confirm an antidepressant-like behavioural impact of LI 160 (100 mg/kg/day, 10 days i.p.) in the OB rat model of depression. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p&lt;0.05) by LI 160 (100 mg/kg/day, 10 days i.p.). However the dose used was generally immunostimulatory active as the increase in leukocyte phagocytosis (p&lt;0.001) was found also in the control group of rats. This immunostimulant effect of the St. Johns wort standardized extract LI 160 might be important in clinics and deserves further investigation.

Czech name

Účinek standardizovaného extraktu z třezalky na leukocytární fagocytózu v potkaním modelu deprese.

Czech description

The effects of St. Johns wort (standardized herbal extract LI 160) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat were studied. The activity of leukocyte zymosan-induced phagocytosis was examinedvia measurement of chemiluminiscence potentiated by luminol. The results confirm an antidepressant-like behavioural impact of LI 160 (100 mg/kg/day, 10 days i.p.) in the OB rat model of depression. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p&lt;0.05) by LI 160 (100 mg/kg/day, 10 days i.p.). However the dose used was generally immunostimulatory active as the increase in leukocyte phagocytosis (p&lt;0.001) was found also in the control group of rats. This immunostimulant effect of the St. Johns wort standardized extract LI 160 might be important in clinics and deserves further investigation.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

Suppl.4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

2

Pages from-to

39-40

UT code for WoS article

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EID of the result in the Scopus database

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