Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010698" target="_blank" >RIV/00216224:14110/04:00010698 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats

Original language description

The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activitiesof animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/exploratory

Czech name

Porovnání úlohy receptorů 5-HT1 a 5-HT2 v regulaci lokomočně-pátracího chování potaknů

Czech description

Výsledky ukázaly na význmanou roli 5-HT1 receptorového systému v regulacích lkomočně-pátrací aktivity potkanů.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GP305%2F02%2FD130" target="_blank" >GP305/02/D130: Functional role of serotonin 5-HT2 receptor subtype in development of methamphetamine dependence</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Homeostasis

ISSN

0960-7560

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

1

Country of publishing house

IT - ITALY

Number of pages

3

Pages from-to

46-48

UT code for WoS article

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EID of the result in the Scopus database

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