Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00010699" target="_blank" >RIV/00216224:14110/04:00010699 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy

Original language description

The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders.

Czech name

Vliv 5-HT1 a 5-HT2 receptorů na aktivitu v i.v. self-administraci metamfetaminu u potkanů v modelu deprese vyvolané olfaktorickou bulbektomií

Czech description

Výsledky ukazují na významný podíl aktivity 5-HT2 receptorového systémů v procesech odměny u potaknů v modelu deprese.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fundamental & Clinical Pharmacology

ISSN

1744-3377

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

1

Pages from-to

45-45

UT code for WoS article

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EID of the result in the Scopus database

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