Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00012984" target="_blank" >RIV/00216224:14110/05:00012984 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain.

Original language description

Peripheral neuropathic pain has been investigated using rat peripheral nerve injury models including unilateral sciatic nerve transection or ligation, spinal nerve ligation or ventral root transection. The experimental models were utilized for the studyof immunofluorescence (IF) staining for IL-1b, IL-6, TNFa and TNFaR1 in the rat DRG. Quantitative and qualitative IF changes in the DRG affected by unilateral nerve injury were compared with the contralateral ones removed from operated animals as well asnaive rats. Ipsi- and contralateral DRG displayed increased IF for TNFa and TNFaR1 when compared with DRG of naive rats. The TNFa IF was increased in both DRG neurons and their satellite glial cells, while enhanced IF for TNFaR1 was observed only at thesurface of satellite glial cells after various types of nerve injury. In addition, ipsilateral DRG exhibited an elevation of TNFa immunoreactivity by invaded ED-1+ macrophages. The IL-1b IF was increased in the DRG neurons following scia

Czech name

Intra- a extraneuronální změny v imunofluorescenční lokalizaci prozánětlivých a protizánětlivých molekul v experimentálních modelech neuropatické bolesti

Czech description

Intra- a extraneuronální změny v imunofluorescenční lokalizaci prozánětlivých a protizánětlivých molekul v experimentálních modelech neuropatické bolesti

Type

D - Article in proceedings

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GA309%2F03%2F1199" target="_blank" >GA309/03/1199: Changes of the satellite glial cells and their extracellular matrix after axotomy - conditions for the sympathetic sprouts in the spinal ganglia?</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Folia Medica Cassoviensia

ISBN

80-7097-607-1

ISSN

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e-ISSN

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Number of pages

1

Pages from-to

22-22

Publisher name

Institute of Neurobiology, Slovak Academy of Science

Place of publication

Košice

Event location

Tatranská Lomnica-Stará Lesná

Event date

Jan 1, 2005

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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