Effect of acute and repeated administration of methamphetamine on the activity of CYP2D in isolated perfused rat liver

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014068" target="_blank" >RIV/00216224:14110/05:00014068 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of acute and repeated administration of methamphetamine on the activity of CYP2D in isolated perfused rat liver

Original language description

The aim of this study was to ascertain the influence of acute and repeated methamphetamine administration on metabolic activity of CYP2D2. The study was performed in the model of isolated perfused rat liver using dextromethorphan as a specific marker ofCYP2D2 activity. Acute administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for two days) significantly increased dextrorphan O-formation in the isolated liver mediated by CYP2D2 at all investigated doses in the 120th min of liver perfusion. Repeated administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for six days) significantly stimulated dextromethorphan O-demethylation via CYP2D2 dose-dependently. Thus, an induction of CYP2D2 metabolic activity was proved in these experiments. With regard to a high level of homology between human and rat CYP isoform studied, the results may have clinical impact in pharmacotherapy of methamphetamine abusers.

Czech name

Vliv akutního a opakovaného podávání metamfetaminu na aktivitu CYP2D na modelu izolovaných perfundovaných jater

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Veterinaria Brno

ISSN

0001-7213

e-ISSN

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Volume of the periodical

74

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

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UT code for WoS article

000232717000003

EID of the result in the Scopus database

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