Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014397" target="_blank" >RIV/00216224:14110/05:00014397 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes
Original language description
Ajmaline decreased the upstroke velocity of action potential and action potential amplitude, increased the action potential duration measured at 50 and 90% repolarization, and reversibly inhibited most components of membrane ionic current in a concentration-dependent manner; IC50 was 27.8 umol/l for INa, 70.8 umol/l for ICa, 25.9 umol/l for Ito, 61.0 umol/l for IK, and 13.3 umol/l for IKATP.
Czech name
Vliv ajmalinu na akcni napeti a iontove proudy u komorovych srdecnich bunek potkana
Czech description
Ajmalin snizoval rychlost depolarizace akcniho napeti a amplitudu akcniho napeti, prodluzoval trvani akcniho napeti merene na urovni 50 a 90% repolarizace a reverzibilne inhiboval hlavni komponenty iontoveho membranoveho proudu v zavislosti na aplikovanekoncentraci; IC50 byla 27.8 umol/l pro INa, 70.8 umol/l pro ICa, 25.9 umol/l pro Ito, 61.0 umol/l pro IK a 13.3 umol/l pro IKATP.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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