Mitoxantrone therapy in rapidly worsening multiple sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00014829" target="_blank" >RIV/00216224:14110/05:00014829 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Mitoxantrone therapy in rapidly worsening multiple sclerosis
Original language description
The aim of the study was to asses the effect and safety of mitoxantrone (MX) therapy in patients with relapsing remitting and secondary progressive multiple sclerosis (MS). Thirty-three patients (10 males, 23 females, mean age 48.5+/-9.9 years) with relapsing remitting and secondary progressive MS were followed. The disability was evaluated using Expanded Disability Status Scale (EDSS). The mean time period from the onset to secondary progressive course of the disease was 9.3+/-9.8 years. Patients, whose disability progression increased by one or more EDSS points per one year, and who did not respond to other therapy, were treated with mitoxantrone. Patients were treated once monthly with intravenous administration of mitoxantrone 12 mg/m2 (not exceeding the maximum cumulative dose of 140 mg/m2) and methylprednisolone 1000 mg. Six pulses were administered in each patient. EDSS score was measured at the beginning of the treatment and after twelve months. Disability progression was evalu
Czech name
Léčba mitoxantronem u rychle progredující roztroušené sklerózy
Czech description
Cílem studie bylo zhodnotit efekt a bezpečnost léčby mitoxantronem (MX) u nemocných s relabující a sekundárně progresivní roztroušenou sklerózou (RS). Bylo sledováno 33 pacientů (10 mužů, 23 žen, o průměrném věku 48,5+/- 9,9 let), neschopnost byla hodnocena pomocí Expanded Disability Status Scale (EDSS). Léčba mitoxantronem byla zavedena u nemocných, u kterých došlo během jednoho roku ke zhoršení EDSS skóre o minimálně 1 bod a nereagovali na jinou léčbu. Pacienti byli léčeni 6 pulsy mitoxantronem intravenózně každý měsíc v dávce 12 mg/m2, (celková kumulativní dávka nepřekročila 140 mg/m2) a metylprednisolonem v dávce 1000 mg. Byla zhodnocena progrese EDSS v průběhu 1 roku.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavské lekárske listy
ISSN
0006-9248
e-ISSN
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Volume of the periodical
106
Issue of the periodical within the volume
3
Country of publishing house
SK - SLOVAKIA
Number of pages
3
Pages from-to
141-143
UT code for WoS article
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EID of the result in the Scopus database
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