Increased plasma levels of sRAGE in patients with diabetic nephropathy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00015385" target="_blank" >RIV/00216224:14110/06:00015385 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Increased plasma levels of sRAGE in patients with diabetic nephropathy
Original language description
Background and Aims: Advanced Glycation End products (AGEs) accumulate in diabetic patients in a greater rate than in age-matched non-diabetic subjects and exert various adverse effects via the Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a 50kDa naturally occurring C-terminally truncated form of RAGE that functions as an inhibitor of AGE-mediated signalling events. Decreased levels of supposedly protective sRAGE were ascertained in patients with macrovascular disease and hypertension. Data about therole of sRAGE in diabetic nephropathy are so far lacking. The aim of the study was to analyse the relationship between sRAGE and renal functions in subjects with diabetic nephropathy and, hereby, implicit protective capacity against AGE-mediated toxicity. Material and Methods: Study was designed as a cross-sectional analysis of a cohort of 255 diabetic patients with variable extent of diabetic nephropathy. Total number of subjects consisted if 36 diabetics with T1DM, 219 with T2DM (appr
Czech name
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Czech description
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Project
<a href="/en/project/KJB501620601" target="_blank" >KJB501620601: Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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