Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00015571" target="_blank" >RIV/00216224:14110/06:00015571 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma

Original language description

We investigated the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. MnSOD genotypes were determined by PCR with subsequent restriction analysis by BsaWI enzyme. Significant differences in allele frequencies between groups were not ascertained. Pursuant theses results, Ala-9Val polymorphism does not seem to be a significant predisposing factor for the bronchial asthma in the Czech population. All the same,indications that polymorphism in the MnSOD might modulate severity of disease in predisposed subjects certainly deserve additional attention and exploration.

Czech name

Funkční polymorfizmus v genu pro superoxid dismutázu (MnSOD) u pacientů s astmatem

Czech description

V práci jsme zkoumaly asociaci funkční varianty Ala-9Val v genu pro MnSOD u astmatu ve studii 626 případů a kontrol. MnSOD genotypy byly stanoveny pomocí PCR s restrikční analýzou enzymem BsaWI. Neprokázaly jsme statisticky významný rozdíl v alelických frekvencích mezi oběma skupinami. Ala-9Val polymorfizmus se tedy nezdá být významným faktorem pro vznik bronchiálního astmatu v české populaci. Úloha této varianty při modulaci závažnosti onemocnění u predisponovaných osob vyžaduje další výzkum.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/GP310%2F03%2FP045" target="_blank" >GP310/03/P045: Analysis of the polymorphisms in the nitric oxide synthase (NOS) genes in atopic asthma and other allergies in the Czech population</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

3

Country of publishing house

SE - SWEDEN

Number of pages

4

Pages from-to

299-302

UT code for WoS article

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EID of the result in the Scopus database

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