Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017176" target="_blank" >RIV/00216224:14110/06:00017176 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays
Original language description
PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patiens in the early stage of the disease develop progression and die from the disease. This study aimed to find individual up/down-regulated genes associated with progression and metastatic potential of colorectal cancers using low-density oligonucleotide microarrays. Molecular characterization of patients at high risk of cancer progression may assist to oncologists in treatment decision by selecting those patients who will need adjuvant chemotherapy. PATIENTS AND METHODS: Patients who underwent surgical resection were divided into different prognostic groups by disease-free survival (DFS>36 month ? good prognosis; DFS<36 month ? bad prognosis). Total RNA was extracted from each frozen tumor specimen and gene expression profiles were obtained using a human oligonucleotide microrray (SuperArray) spotted with 128 genes known to be involved in metastas
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9076" target="_blank" >NR9076: Gene expression profiling-based prediction of treatment response for patient with locally advanced rectal cancer treated by chemotherapy and radiotherapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
sborník XX. BIOCHEMICKÝ ZJAZD
ISBN
80-969532-6-5
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
Slovenská společnost pro biochémiu a molekulárnu biologii, člen IUMBM a FEBS
Place of publication
Piešťany
Event location
Piešťany, Slovenská republika
Event date
Jan 1, 2006
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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