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Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00017176" target="_blank" >RIV/00216224:14110/06:00017176 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Molecular characterization of primary colorectal cancers with progressive metastatic phenotype by oligonucleotide microarrays

  • Original language description

    PURPOSE: Colorectal cancer (CRC) is one of the most common malignancies. Unfortunately a significant proportion of surgically cured patiens in the early stage of the disease develop progression and die from the disease. This study aimed to find individual up/down-regulated genes associated with progression and metastatic potential of colorectal cancers using low-density oligonucleotide microarrays. Molecular characterization of patients at high risk of cancer progression may assist to oncologists in treatment decision by selecting those patients who will need adjuvant chemotherapy. PATIENTS AND METHODS: Patients who underwent surgical resection were divided into different prognostic groups by disease-free survival (DFS&gt;36 month ? good prognosis; DFS&lt;36 month ? bad prognosis). Total RNA was extracted from each frozen tumor specimen and gene expression profiles were obtained using a human oligonucleotide microrray (SuperArray) spotted with 128 genes known to be involved in metastas

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9076" target="_blank" >NR9076: Gene expression profiling-based prediction of treatment response for patient with locally advanced rectal cancer treated by chemotherapy and radiotherapy</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    sborník XX. BIOCHEMICKÝ ZJAZD

  • ISBN

    80-969532-6-5

  • ISSN

  • e-ISSN

  • Number of pages

    1

  • Pages from-to

  • Publisher name

    Slovenská společnost pro biochémiu a molekulárnu biologii, člen IUMBM a FEBS

  • Place of publication

    Piešťany

  • Event location

    Piešťany, Slovenská republika

  • Event date

    Jan 1, 2006

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article