Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00031735" target="_blank" >RIV/00216224:14110/06:00031735 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Gene expression of the phenylethanolamine N-methyltransferase is differently modulated in cardiac atria and ventricles
Original language description
Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Although most profuse in adrenal medulla, PNMT is expressed also in the heart, particularly in cardiac atriaand ventricles. In atria, the PNMT mRNA is much more abundant compared to ventricles. In this work we aimed to find out, whether there is difference in modulation of the PNMT gene expression in cardiac atria and ventricles. We used three methodological approaches - cold as a model of mild stress, hypoxia as a model of cardiac ischemic injury and transgenic rats with incorporated mouse renin gene [TGR (mREN-2)27], to determine involvement of renin-angiotensin pathway in the PNMT gene expression. We havefound that PNMT gene expression was modulated differently in cardiac atria and ventricles. In atria PNMT mRNA levels were increased by hypoxia, while cold stress decreased PNMT mRNA levels.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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