Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00023354" target="_blank" >RIV/00216224:14110/07:00023354 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression

Original language description

The purpose of the study was to test a potential antidepressant effect of the 3rd generation antiepileptic tiagabine in rats chronically stressed by anosmia due to bilateral olfactory bulbectomy (OB), which is a well-established animal model of human depression resembling behavioural, immune and endocrine changes (Leonard and Tuite, 1981). OB rats show significant increase in locomotor/exploratory activities in the open-field test, and altered plasma stress hormone levels and suppressed phagocytosis ofleukocytes what we have examined in the present experiments. After repeated tiagabine (12 mg/kg/day, IP) administration we measured the locomotor activity in the open-field test, adrenalin, noradrenaline, dopamine and corticosterone plasma levels and theleukocyte phagocytic function. Also the differential white blood cell counts were measured. Repeated tiagabine treatment elicited a significant decrease of the locomotor hyperactivity in the open field test. Taking into account that clin

Czech name

Aplikace tiagabinu je spojená s neurochemickými a imunitními změnami a alterací chování v potkaním modelu deprese - olfaktorické bulbektomii.

Czech description

Cílem práce bylo studium potenciálních antidepresivních účinků tiagabinu s využitím potkaního modelu deprese - bilaterální olfaktorické bulbektomie (OB). Sledovali jsme změny lokomotorické aktivity OB potkanu v testu volného pole, změny fagocytární aktivity leukocytů a změny hladin stresových hormonů (noradrenalinu, adrenalinu, dopaminu a kortikosteronu). Opakované podávání tiagabinu (12 mg/kg/day, IP) vedlo k normalizaci chování OB zvířat. Snížená hladina noradrenalinu v modelu deprese byla také normalizována po tiagabinu.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacopsychiatry

ISSN

0176-3679

e-ISSN

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Volume of the periodical

2007

Issue of the periodical within the volume

40

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

1-6

UT code for WoS article

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EID of the result in the Scopus database

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