Oral garenoxacin in the treatment of acute bacterial maxillary sinusitis: A phase II, multicenter, noncomparative, open-label study in adult patients undergoing sinus aspiration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00050902" target="_blank" >RIV/00216224:14110/07:00050902 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.clinthera.2007.08.002" target="_blank" >http://dx.doi.org/10.1016/j.clinthera.2007.08.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinthera.2007.08.002" target="_blank" >10.1016/j.clinthera.2007.08.002</a>

Result language

angličtina

Original language name

Oral garenoxacin in the treatment of acute bacterial maxillary sinusitis: A phase II, multicenter, noncomparative, open-label study in adult patients undergoing sinus aspiration

Original language description

The aim of this study was to assess the efficacy and tolerability of garenoxacin in adults with acute bacterial maxillary sinusitis undergoing a pretreatment diagnostic sinus aspirate. Garenoxacin is a des-F(6)-quinolone with in vitro activity against key respiratory pathogens, including Streptococcus pneumoniae, Hemophilus influenzae, Staphylococcus aureus, and Moraxella catarrhalis. This Phase II, multicenter, noncomparative, open-label study was conducted at 30 centers in the United States, Mexico, Argentina, and Europe. Conclusion: In this population of patients with signs and symptoms of acute maxillary sinusitis, oral garenoxacin 400 mg QD for 5 or 10 days eradicated 94 % of bacterial pathogens associated with acute bacterial sinusitis in this population and appeared to be well tolerated in adults.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Therapeutics

ISSN

0149-2918

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

1632-1644

UT code for WoS article

000249682900009

EID of the result in the Scopus database

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