MICROCHIMERISM - LOOK INTO THE INCIPIENT AML RELAPSE?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00027839" target="_blank" >RIV/00216224:14110/08:00027839 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
MICROCHIMERISM - LOOK INTO THE INCIPIENT AML RELAPSE?
Original language description
The reoccurrence or increase in autologous hematopoiesis after an allogeneic hematopoietic cell transplantation (allo-HCT) has been linked with incipient leukemia relapse, however, clear definition of such "emergency" in terms of microchimerism has not been defined yet. Aims Since the usual minimal residual disease (MRD) analysis is more sensitive than conventional chimerism analysis and MRD-guided intervention is routinely used after transplantation, here we wanted to explore if more sensitive chimerism analysis (microchimerism) could be used for earlier detection of imminent relapse. Methods We compared conventional polymerase chain reaction (PCR) of minisatellite, microsatellite, or sex specific regions with following fragment analysis (FA) (limit of quantification ~1%), with real-time quantitative PCR (RQ-PCR) of insertion/deletion and sex polymorphism (limit of quantification ~0.1%).
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů