Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00028225" target="_blank" >RIV/00216224:14110/08:00028225 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/08:#0000346

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.

Original language description

Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokineresponses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data inHIES.

Czech name

Stimulace Toll-like receptorů periferních mononukleárů pacientů s hyper IgE syndromem vede k tvorbě TNF alfa

Czech description

Stimulace Toll-like receptorů periferních mononukleárů pacientů s hyper IgE syndromem vede k tvorbě TNF alfa

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/NR9192" target="_blank" >NR9192: Screening of mutations and polymorphisms in neonatal Fc receptor gene in patients with primary disorders of antibody production</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Archives Allergy and Immunology

ISSN

1018-2438

e-ISSN

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Volume of the periodical

146

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

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UT code for WoS article

000255896000002

EID of the result in the Scopus database

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