Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00033484" target="_blank" >RIV/00216224:14110/08:00033484 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
Original language description
Aim: The pathophysiology of pre-eclampsia, one of the leading causes of maternal mortality worldwide, still remains unclear. Recently, it has been suggested that impaired regulation of complex interactions among various adipokines plays an important rolein the development of pre-eclampsia. The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestationalhypertension, proteinuria and various measures of reduced fetal growth) in the Czech pre-eclamptic population. Methods: The case-control study comprised a total of 123 pre-eclamptic women and 150 healthy controls of similar age and parity distribution. They were genotyped for the LEP -2548G/A (5-untranslated region) and APM1 T94G (exon 2) polymorphisms using polymerase chain reaction. Results: The allele frequency of the LEP -2548G polymorphism was 0.541 in the pre-eclamptic group versus
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Obstetrics and Gynaecology Research
ISSN
1341-8076
e-ISSN
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Volume of the periodical
2008
Issue of the periodical within the volume
XX
Country of publishing house
JP - JAPAN
Number of pages
8
Pages from-to
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UT code for WoS article
000259270800014
EID of the result in the Scopus database
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