MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F09%3A00029107" target="_blank" >RIV/00216224:14110/09:00029107 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/09:00009641

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders

Original language description

Several lines of evidence suggest that chemokines play an important role in asthma and allergy. We analyzed polymorphisms at -2518A/G and -2076A/T of MCP-1 and V64I of CCR2 gene in healthy subjects (n=306) and allergic patients (n=332). Allele and genotype frequencies did not differ significantly between groups. Nevertheless, MCP-1 variants were associated with allergen sensitization. The results suggest that MCP-1, but not CCR2 gene variants, may participate in the pathogenesis of allergic phenotypes at least in the Caucasian population.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/GA310%2F06%2F0827" target="_blank" >GA310/06/0827: Genetic determinants of the pro-/antioxidant balance in the pathogenesis of respiratory diseases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Int J Immunogenet

ISSN

1744-3121

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

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UT code for WoS article

000262667000010

EID of the result in the Scopus database

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