Paliperidon mediated modification of cortical inhibition

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F09%3A00037345" target="_blank" >RIV/00216224:14110/09:00037345 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/09:#0000799

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Paliperidon mediated modification of cortical inhibition

Original language description

Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission.

Czech name

Paliperidon mediated modification of cortical inhibition

Czech description

Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/NS9890" target="_blank" >NS9890: Functional brain correlates related to negative symptoms of schizophrenia treatment by repetitive transcranial magnetic stimulation</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

2009

Issue of the periodical within the volume

30

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

00027219930

EID of the result in the Scopus database

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