Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F09%3A00040101" target="_blank" >RIV/00216224:14110/09:00040101 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/09:#0000317

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer

Original language description

There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

<a href="/en/project/NR9200" target="_blank" >NR9200: Dynamics of oxidative stress during oncotherapy and prognosis of patients with head and neck carcinomas</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

10/2009

Issue of the periodical within the volume

29

Country of publishing house

GR - GREECE

Number of pages

5

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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