Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00044686" target="_blank" >RIV/00216224:14110/10:00044686 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/10:00003114

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study

Original language description

The aim of this work was to study the distribution of heavy metals and of subsequently developed morphological changes in the liver of female mice and their foetuses after oral administration of high doses of lead, mercury, and cadmium (0.03 mg of metalper mouse and day). Heavy metals were administered to pregnant female mice on days 9 to 20 of pregnancy. The animals were euthanised by cervical dislocation. Samples of mother and foetal liver were subsequently collected and processed by means of the common technique for light and electron microscopy. Histochemical reaction based on metal conversion into appropriate sulphide that conjugates with silver was used for detection of heavy metals. Deposits of heavy metals were found at the periphery of lobules of the central vein in the liver of female mice. On the contrary, in the liver of foetuses no predilection site for localisation of the reaction product could be identified.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Veterinaria

ISSN

0001-7213

e-ISSN

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Volume of the periodical

2010

Issue of the periodical within the volume

79

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

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UT code for WoS article

000280221700008

EID of the result in the Scopus database

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