Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00046981" target="_blank" >RIV/00216224:14110/10:00046981 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/10:00003017

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention

Original language description

Introduction: The aim of the study was to compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). Methods: We modified a previously published rabbit model of arterial thrombosis prevention to compare UFHand two different doses of two LMWH fragments - nadroparin and enoxaparin. Thrombosis was triggered by vessel wall injury and critical stenosis. Blood flow monitored by a flow probe. The primary endpoints were: cumulative flow, time to occlusion and residual clot weight. Thirty six animals were split into 6 groups. Control groups were given saline or UFH and four more groups were used to compare LMWH's at 2 different doses. Results: In our study, all treatments were superior to the saline control group.UFH was inferior to both LMWH's for all primary endpoints. There were no differences between the LMWH's except for cumulative flow at high doses. Conclusions: This study revealed no relevant differences between nadroparin and enoxaparin.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thrombosis Research

ISSN

0049-3848

e-ISSN

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Volume of the periodical

126

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

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UT code for WoS article

000278654600012

EID of the result in the Scopus database

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