Surgical downstaging and neo-adjuvant therapy in metastatic colorectal carcinoma with irinotecan drug-eluting beads: a multi-institutional study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00051437" target="_blank" >RIV/00216224:14110/10:00051437 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/j.1477-2574.2009.00117.x" target="_blank" >http://dx.doi.org/10.1111/j.1477-2574.2009.00117.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1477-2574.2009.00117.x" target="_blank" >10.1111/j.1477-2574.2009.00117.x</a>

Result language

angličtina

Original language name

Surgical downstaging and neo-adjuvant therapy in metastatic colorectal carcinoma with irinotecan drug-eluting beads: a multi-institutional study

Original language description

Background: Neoadjuvant chemotherapy for potentially resectable metastatic colorectal cancer (MCC) is becoming a more common treatment algorithm. The aim of the present study was to evaluate the efficacy of precision hepatic arterial Irinotecan therapy in unresectable MCC. Methods: An open-label, multi-centre, multi-national single arm study of MCC patients, who received hepatic arterial irinotecan. Primary endpoints were safety, tolerance and metastatic tumour resection. Results: Fifty-five patients with metastatic colorectal to the liver underwent a total of 90 hepatic arterial irinotecan treatments. The extent of liver involvement was &lt;25% in 75% of the patients (n = 41), between 26 and 50% in 15% of the patients (n = 11) and &gt;50% in 10% of the patients (n = 24). The median number of hepatic lesions was four (range 1-20), with a median total size of all target lesions of 9 cm (range 5.5-28 cm) with 50% of patients having bilobar tumour distribution.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

HPB (Oxford)

ISSN

1365-182X

e-ISSN

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Volume of the periodical

12,2010

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

31-36

UT code for WoS article

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EID of the result in the Scopus database

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