Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00051729" target="_blank" >RIV/00216224:14110/10:00051729 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients
Original language description
During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughoutthe study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 8th World Congress on Trauma, Shock, Inflammation and Sepsis, Selected Papers
ISBN
978-88-6521-024-6
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
33-37
Publisher name
Thomson Reuters
Place of publication
Philadelphia
Event location
Munich, Germany
Event date
Mar 9, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000281967800007