CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00051816" target="_blank" >RIV/00216224:14110/10:00051816 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.canep.2010.06.008" target="_blank" >http://dx.doi.org/10.1016/j.canep.2010.06.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.canep.2010.06.008" target="_blank" >10.1016/j.canep.2010.06.008</a>
Alternative languages
Result language
angličtina
Original language name
CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify risk of sporadic pancreatic cancer
Original language description
Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR = 5.14; 95% Cl = 0.94-28.23) but the observed association was non-significant (p = 0.057). The most frequent I157T mutation did not alter the pancreatic cancer risk and neither the followed deletion of 5395 bp nor c.1100delC were found in any of pancreatic cases. We conclude that the I157T, other alterations in its proximity, del5395 and c.1100delC in CHEK2 do not predispose to pancreatic cancer risk in the Czech population.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer epidemiology
ISSN
1877-7821
e-ISSN
—
Volume of the periodical
34
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
3
Pages from-to
656-658
UT code for WoS article
000283974700024
EID of the result in the Scopus database
—