Importance of screening of IgG anti-IgA antibodies in hypogammaglobulinemic subjects to prevent anaphylactoid reactions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00058965" target="_blank" >RIV/00216224:14110/10:00058965 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Importance of screening of IgG anti-IgA antibodies in hypogammaglobulinemic subjects to prevent anaphylactoid reactions
Original language description
Anti-IgA antibodies can cause severe anaphylactoid reactions in the case of blood transfusion or substitution immunoglobulin therapy in patients with hypogammaglobulinemia. We found a significant amount of anti-IgA antibodies in 10 % of patients with themost common primary hypogammaglobulinemia (selective IgA deficiency and common variable immunodeficiencies) where the serum IgA level was lower than 0.05 g/L. Knowledge of the presence of antibodies against IgA is important in clinical practice in orderto prevent an anaphylactic reaction during blood transfusion or during immunoglobulin substitution therapy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/7E08062" target="_blank" >7E08062: Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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