Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00051585" target="_blank" >RIV/00216224:14110/11:00051585 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3748/wjg.v17.i5.609" target="_blank" >http://dx.doi.org/10.3748/wjg.v17.i5.609</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3748/wjg.v17.i5.609" target="_blank" >10.3748/wjg.v17.i5.609</a>

Result language
angličtina
Original language name
Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917
Original language description
AIM: To evaluate bacteriocinogeny in short-term high-dose indomethacin administration with or without probiotic Escherichia coli Nissle 1917 (EcN) in experimental pigs. METHODS: Twenty-four pigs entered the study: Group A (controls), Group B (probioticsalone), Group C (indomethacin alone) and Group D (probiotics and indomethacin). EcN (3.5x1010 bacteria/d for 14 d) and/or indomethacin (15 mg/kg per day for 10 d) were administrated orally. Anal smears before and smears from the small and large intestinewere taken from all animals. Bacteriocin production was determined with 6 different indicator strains. RESULTS: The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria (parallel genotypes A,B1, B2 and D found). CONCLUSION: EcN did not exert long-term liveability in the porcine intestine. All experimental pigs remained methanogenic. Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/NS9665" target="_blank" >NS9665: Molecular typing of bacteriocins produced by strains of Escherichia coli isolated from clinical material: identification of colicin and microcin types among commensal and pathogenic strains</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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