Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00053036" target="_blank" >RIV/00216224:14110/11:00053036 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/11:#0001241

Result on the web

<a href="http://dx.doi.org/10.1182/blood-2010-12-323980" target="_blank" >http://dx.doi.org/10.1182/blood-2010-12-323980</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1182/blood-2010-12-323980" target="_blank" >10.1182/blood-2010-12-323980</a>

Result language

angličtina

Original language name

Chemoimmunotherapy with O-FC in previously untreated patients with chronic lymphocytic leukemia

Original language description

We conducted an international phase 2 trial to evaluate 2 dose levels of ofatumumab, a human CD20 mAb, combined with fludarabine and cyclophosphamide (O-FC) as frontline therapy for chronic lymphocytic leukemia (CLL). Patients with active CLL were randomized to ofatumumab 500 mg (n = 31) or 1000 mg (n = 30) day 1, with fludarabine 25 mg/m2 and cyclophosphamide 250 mg/m2 days 2-4, course 1; days 1-3, courses 2-6; every 4 weeks for 6 courses. The first ofatumumab dose was 300 mg for both cohorts. The median age was 56 years; 13% of patients had a 17p deletion; 64% had B2-microglobulin &gt; 3.5 mg/L. Based on the 1996 National Cancer Institute Working Group (NCI-WG) guidelines, the complete response (CR) rate as assessed by an independent review committeewas 32% for the 500-mg and 50% for the 1000-mg cohort; the overall response (OR) rate was 77% and 73%, respectively.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood

ISSN

0006-4971

e-ISSN

—

Volume of the periodical

117

Issue of the periodical within the volume

24

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

6450-6458

UT code for WoS article

000291684300010

EID of the result in the Scopus database

—