Oral contraceptives and risk of ovarian and breast cancers in BRCA mutation carriers: a meta-analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00053296" target="_blank" >RIV/00216224:14110/11:00053296 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/11:10110 RIV/00064165:_____/11:10110
Result on the web
<a href="http://dx.doi.org/10.1586/ERA.11.38" target="_blank" >http://dx.doi.org/10.1586/ERA.11.38</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1586/ERA.11.38" target="_blank" >10.1586/ERA.11.38</a>
Alternative languages
Result language
angličtina
Original language name
Oral contraceptives and risk of ovarian and breast cancers in BRCA mutation carriers: a meta-analysis
Original language description
Prophylactic salpingo-oophorectomy is currently the only effective strategy available for decreasing ovarian cancer risk in BRCA1/2 mutation carriers. Significantly decreased risk of ovarian cancer associated with the use of combined oral contraceptives(COCs) was shown in the general population, which could be an alternative approach for those who do not accept risk-reducing surgery. Cohort, case?control and case?case studies published in English up to December 2009 reporting the association of ovarianor breast cancer risk with the use of COCs and presenting BRCA status were selected for meta-analysis. Meta-analysis of three case?control studies showed a significant risk reduction of ovarian cancer in BRCA1/2 mutation carriers who were associated with any past COC use and significant trend by duration of COC use (OR: 0.95; 95% CI: 0.93?0.97). No significant increase in breast cancer risk associated with COC use has been found in case?control studies in BRCA1 (OR: 1.08; p = 0.250), in
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP301%2F08%2FP103" target="_blank" >GP301/08/P103: Promoter methylation analysis of the genes downstream of BRCA1 and BRCA1 - comparison of methylation profiles in mutation carriers and non-carriers</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Expert Review of Anticancer Therapy
ISSN
1473-7140
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
1197-1207
UT code for WoS article
000294978600012
EID of the result in the Scopus database
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