Underlying mechanisms of ovarian cancer risk reduction after tubal ligation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00054101" target="_blank" >RIV/00216224:14110/11:00054101 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1600-0412.2011.01114.x" target="_blank" >http://dx.doi.org/10.1111/j.1600-0412.2011.01114.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1600-0412.2011.01114.x" target="_blank" >10.1111/j.1600-0412.2011.01114.x</a>

Result language
angličtina
Original language name
Underlying mechanisms of ovarian cancer risk reduction after tubal ligation
Original language description
A recently published meta-analysis of 21 studies confirmed a protective effect of tubal ligation on the risk of invasive ovarian cancer. This protective measure has received little attention, particularly due to the elusive underlying mechanism. In thiscommentary we discuss available data concerning the contribution of different potential mechanisms by which tubal ligation might prevent ovarian cancer. Included were studies published in English, identified through a literature search using PubMed and EMBASE. Four main mechanisms are discussed: (a) a screening effect, (b) alteration of ovarian function, (c) a mechanical barrier against ascending carcinogenic agents and (d) prevention of endometrial and proximal Fallopian tube cell ascent. There are arguments supporting the major role of a mechanical barrier to the ascent of endometrial cells into the peritoneal cavity for decreasing risk of ovarian cancer after tubal ligation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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