No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00054111" target="_blank" >RIV/00216224:14110/11:00054111 - isvavai.cz</a>

Alternative codes found

RIV/61383082:_____/11:0071 RIV/00216208:11110/11:9771 RIV/00064165:_____/11:9771

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Original language description

Background. Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role inoxidative stress defense. Objective. To assess the effect of promotervariations of HMOX1 andUGT1A1 genes on the progression of fibrosis in patients chronically infected with the hepatitis C virus (HCV). Material and methods. The study was performed on146 chronic HCV infection patients, plus 146 age- and sex-matched healthy subjects. The (GT)nand (TA)n dinucleotide variations in HMOX1 and UGT1A1 gene promoters, respectively, were determined by fragment analysis in all subjects. Results. No differences were found in the frequencies of each particular allele of both genes, between HCV patientsand a control group (p &gt; 0.05). Furthermore, no association was detected (p &gt; 0.05) between either the HMOX1 or the UGT1A1 promoter variants and the individual histological stages of liver disease in the HCV positive patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/NR9412" target="_blank" >NR9412: Role of heme oxygenase in the pathogenesis of hepatocelular injury in chronic HCV infection</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of Hepatology

ISSN

1665-2681

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

MX - MEXICO

Number of pages

7

Pages from-to

445-451

UT code for WoS article

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EID of the result in the Scopus database

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