Long-term results of allogeneic hematopoietic stem cell transplantation after reduced-intensity conditioning with busulfan, fludarabine, and antithymocyte globulin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00054666" target="_blank" >RIV/00216224:14110/11:00054666 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/11:#0001393

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2011_05_406" target="_blank" >http://dx.doi.org/10.4149/neo_2011_05_406</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2011_05_406" target="_blank" >10.4149/neo_2011_05_406</a>

Result language

angličtina

Original language name

Long-term results of allogeneic hematopoietic stem cell transplantation after reduced-intensity conditioning with busulfan, fludarabine, and antithymocyte globulin

Original language description

Reduced-intensity conditioning (RIG) is widely used for allogeneic stem cell transplantation (SCT). Here we present our long-term experience with RIG regimen consisting of fludarabine (30 mg/m(2)/day on days -10 to -5), busulfan (4mg/kg/day on days -6 and -5) and antithymocyte globulin (ATG Fresenius, 10 mg/kg/day on days -4 to -1) (Flu-Bu-ATG) in a cohort of 71 patients with various hematological malignancies including chronic myeloid leukemia (24 patients), acute myeloid leukemia (19 patients), lymphoma (20 patients), multiple myeloma (3 patients), myelodysplastic syndrome (3 patients), and myelofibrosis (2 patients). The median age was 50 years. The overall response rate was 87%, including 83% CR and 4% PR. The incidence of acute and chronic GVHD was 35% and 52% and the cumulative incidence of non-relapse mortality at 1 year and 4 years was 8% and 14%. With the median follow-up of 55.0 months, the 2- and 4-year event-free survival (EFS) was 49.0% and 40.3%, and the overall survival

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

5

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

406-414

UT code for WoS article

000295309700007

EID of the result in the Scopus database

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