MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055225" target="_blank" >RIV/00216224:14110/11:00055225 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/11:#0001592 RIV/00209805:_____/11:#0000191
Result on the web
<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x" target="_blank" >10.1111/j.1582-4934.2011.01317.x</a>
Alternative languages
Result language
angličtina
Original language name
MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
Original language description
MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11214" target="_blank" >NT11214: Identification and functional characterization of microRNAs with predictive significance in patients with glioblastoma</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1636-1644
UT code for WoS article
000292700800002
EID of the result in the Scopus database
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